GrippeEspagneV1, Main, Exploration, bibRecord, 000218

Influenza vaccine effectiveness in preventing influenza A(H3N2)-related hospitalizations in adults targeted for vaccination by type of vaccine: a hospital-based test-negative study, 2011-2012 A(H3N2) predominant influenza season, Valencia, Spain.

Identifieur interne : 000218 ( Main/Exploration ); précédent : 000217; suivant : 000219

Influenza vaccine effectiveness in preventing influenza A(H3N2)-related hospitalizations in adults targeted for vaccination by type of vaccine: a hospital-based test-negative study, 2011-2012 A(H3N2) predominant influenza season, Valencia, Spain.

Auteurs : Joan Puig-Barberà [Espagne] ; Juan García-De-Lomas [Espagne] ; Javier Díez-Domingo [Espagne] ; Alberto Arnedo-Pena [Espagne] ; Montserrat Ruiz-García [Espagne] ; Ram N Lim N-Ramírez [Espagne] ; Silvia Pérez-Vilar [Espagne] ; José Luis Mic Esparza [Espagne] ; Miguel Tortajada-Girbés [Espagne] ; Concha Carratalá-Munuera [Espagne] ; Rosa Larrea-González [Espagne] ; Juan Manuel Beltrán-Garrido [Espagne] ; Maria Del Carmen Otero-Reigada [Espagne] ; Joan Mollar-Maseres [Espagne] ; Patricia Correcher-Medina [Espagne] ; Germán Schwarz-Chavarri [Espagne] ; Vicente Gil-Guillén [Espagne]

Source :

PloS one [ 1932-6203 ] ; 2014.

RBID : pubmed:25392931

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Espagne (MeSH), Femelle (MeSH), Grippe humaine (prévention et contrôle), Hospitalisation (MeSH), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Recherche comparative sur l'efficacité (MeSH), Sous-type H3N2 du virus de la grippe A (immunologie), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Vaccins antigrippaux (administration et posologie), Études prospectives (MeSH).
MESH :
- administration et posologie : Vaccins antigrippaux.
- immunologie : Sous-type H3N2 du virus de la grippe A.
- prévention et contrôle : Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Espagne, Femelle, Hospitalisation, Humains, Jeune adulte, Mâle, Recherche comparative sur l'efficacité, Sujet âgé, Sujet âgé de 80 ans ou plus, Études prospectives.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Comparative Effectiveness Research (MeSH), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Influenza A Virus, H3N2 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza, Human (prevention & control), Male (MeSH), Middle Aged (MeSH), Prospective Studies (MeSH), Spain (MeSH), Young Adult (MeSH).
MESH :
- chemical , administration & dosage : Influenza Vaccines.
- geographic : Spain.
- immunology : Influenza A Virus, H3N2 Subtype.
- prevention & control : Influenza, Human.
- Adolescent, Adult, Aged, Aged, 80 and over, Comparative Effectiveness Research, Female, Hospitalization, Humans, Male, Middle Aged, Prospective Studies, Young Adult.

Abstract

BACKGROUND

Most evidence of the effectiveness of influenza vaccines comes from studies conducted in primary care, but less is known about their effectiveness in preventing serious complications. Here, we examined the influenza vaccine effectiveness (IVE) against hospitalization with PCR-confirmed influenza in the predominant A(H3N2) 2011-2012 influenza season.

METHODS

A hospital-based, test-negative study was conducted in nine hospitals in Valencia, Spain. All emergency admissions with a predefined subset of symptoms were eligible. We enrolled consenting adults age 18 and over, targeted for influenza vaccination because of comorbidity, with symptoms of influenza-like-illness within seven days of admission. We estimated IVE as (1-adjusted vaccination odds ratio)*100 after accounting for major confounders, calendar time and recruitment hospital.

RESULTS

The subjects included 544 positive for influenza A(H3N2) and 1,370 negative for influenza admissions. Age was an IVE modifying factor. Regardless of vaccine administration, IVE was 72% (38 to 88%) in subjects aged under 65 and 21% (-5% to 40%) in subjects aged 65 and over. By type of vaccine, the IVE of classical intramuscular split-influenza vaccine, used in subjects 18 to 64, was 68% (12% to 88%). The IVE for intradermal and virosomal influenza vaccines, used in subjects aged 65 and over, was 39% (11% to 58%) and 16% (-39% to 49%), respectively.

CONCLUSIONS

The split-influenza vaccine was effective in preventing influenza-associated hospitalizations in adults aged under 65. The intradermal vaccine was moderately effective in those aged 65 and over.

DOI: 10.1371/journal.pone.0112294
PubMed: 25392931
PubMed Central: PMC4230985

Affiliations:

Espagne

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 00190
to stream Main, to step Curation: 000190

Le document en format XML

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<author><name sortKey="Diez Domingo, Javier" sort="Diez Domingo, Javier" uniqKey="Diez Domingo J" first="Javier" last="Díez-Domingo">Javier Díez-Domingo</name>
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<author><name sortKey="Arnedo Pena, Alberto" sort="Arnedo Pena, Alberto" uniqKey="Arnedo Pena A" first="Alberto" last="Arnedo-Pena">Alberto Arnedo-Pena</name>
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<author><name sortKey="Ruiz Garcia, Montserrat" sort="Ruiz Garcia, Montserrat" uniqKey="Ruiz Garcia M" first="Montserrat" last="Ruiz-García">Montserrat Ruiz-García</name>
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<author><name sortKey="Lim N Ramirez, Ram N" sort="Lim N Ramirez, Ram N" uniqKey="Lim N Ramirez R" first="Ram N" last="Lim N-Ramírez">Ram N Lim N-Ramírez</name>
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<author><name sortKey="Perez Vilar, Silvia" sort="Perez Vilar, Silvia" uniqKey="Perez Vilar S" first="Silvia" last="Pérez-Vilar">Silvia Pérez-Vilar</name>
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<author><name sortKey="Mic Esparza, Jose Luis" sort="Mic Esparza, Jose Luis" uniqKey="Mic Esparza J" first="José Luis" last="Mic Esparza">José Luis Mic Esparza</name>
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<author><name sortKey="Tortajada Girbes, Miguel" sort="Tortajada Girbes, Miguel" uniqKey="Tortajada Girbes M" first="Miguel" last="Tortajada-Girbés">Miguel Tortajada-Girbés</name>
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<author><name sortKey="Carratala Munuera, Concha" sort="Carratala Munuera, Concha" uniqKey="Carratala Munuera C" first="Concha" last="Carratalá-Munuera">Concha Carratalá-Munuera</name>
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<country xml:lang="fr">Espagne</country>
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<wicri:noRegion>Alicante</wicri:noRegion>
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<author><name sortKey="Larrea Gonzalez, Rosa" sort="Larrea Gonzalez, Rosa" uniqKey="Larrea Gonzalez R" first="Rosa" last="Larrea-González">Rosa Larrea-González</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital General de Castellón, Castellón, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital General de Castellón, Castellón</wicri:regionArea>
<wicri:noRegion>Castellón</wicri:noRegion>
</affiliation>
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<author><name sortKey="Beltran Garrido, Juan Manuel" sort="Beltran Garrido, Juan Manuel" uniqKey="Beltran Garrido J" first="Juan Manuel" last="Beltrán-Garrido">Juan Manuel Beltrán-Garrido</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital General de Castellón, Castellón</wicri:regionArea>
<wicri:noRegion>Castellón</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Otero Reigada, Maria Del Carmen" sort="Otero Reigada, Maria Del Carmen" uniqKey="Otero Reigada M" first="Maria Del Carmen" last="Otero-Reigada">Maria Del Carmen Otero-Reigada</name>
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<author><name sortKey="Mollar Maseres, Joan" sort="Mollar Maseres, Joan" uniqKey="Mollar Maseres J" first="Joan" last="Mollar-Maseres">Joan Mollar-Maseres</name>
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</affiliation>
</author>
<author><name sortKey="Correcher Medina, Patricia" sort="Correcher Medina, Patricia" uniqKey="Correcher Medina P" first="Patricia" last="Correcher-Medina">Patricia Correcher-Medina</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Lluis Alcanyis, Xativa, Spain, 12 Centro de Salud San Blas, Alicante, Spain, 13 Hospital de Elda, Elda</wicri:regionArea>
<wicri:noRegion>Elda</wicri:noRegion>
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<author><name sortKey="Schwarz Chavarri, German" sort="Schwarz Chavarri, German" uniqKey="Schwarz Chavarri G" first="Germán" last="Schwarz-Chavarri">Germán Schwarz-Chavarri</name>
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<wicri:noRegion>Alicante</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gil Guillen, Vicente" sort="Gil Guillen, Vicente" uniqKey="Gil Guillen V" first="Vicente" last="Gil-Guillén">Vicente Gil-Guillén</name>
<affiliation wicri:level="1"><nlm:affiliation>Cátedra de Medicina de Familia, Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan, Alicante, Spain; Hospital de Elda, Elda, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Cátedra de Medicina de Familia, Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan, Alicante, Spain; Hospital de Elda, Elda</wicri:regionArea>
<wicri:noRegion>Elda</wicri:noRegion>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Influenza vaccine effectiveness in preventing influenza A(H3N2)-related hospitalizations in adults targeted for vaccination by type of vaccine: a hospital-based test-negative study, 2011-2012 A(H3N2) predominant influenza season, Valencia, Spain.</title>
<author><name sortKey="Puig Barbera, Joan" sort="Puig Barbera, Joan" uniqKey="Puig Barbera J" first="Joan" last="Puig-Barberà">Joan Puig-Barberà</name>
<affiliation wicri:level="1"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain; Centro de Salud Pública de Castellón, Castellón, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain; Centro de Salud Pública de Castellón, Castellón</wicri:regionArea>
<wicri:noRegion>Castellón</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garcia De Lomas, Juan" sort="Garcia De Lomas, Juan" uniqKey="Garcia De Lomas J" first="Juan" last="García-De-Lomas">Juan García-De-Lomas</name>
<affiliation wicri:level="1"><nlm:affiliation>Instituto Valenciano de Microbiología, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Instituto Valenciano de Microbiología, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Diez Domingo, Javier" sort="Diez Domingo, Javier" uniqKey="Diez Domingo J" first="Javier" last="Díez-Domingo">Javier Díez-Domingo</name>
<affiliation wicri:level="1"><nlm:affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Arnedo Pena, Alberto" sort="Arnedo Pena, Alberto" uniqKey="Arnedo Pena A" first="Alberto" last="Arnedo-Pena">Alberto Arnedo-Pena</name>
<affiliation wicri:level="1"><nlm:affiliation>Centro de Salud Pública de Castellón, Castellón, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Salud Pública de Castellón, Castellón</wicri:regionArea>
<wicri:noRegion>Castellón</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruiz Garcia, Montserrat" sort="Ruiz Garcia, Montserrat" uniqKey="Ruiz Garcia M" first="Montserrat" last="Ruiz-García">Montserrat Ruiz-García</name>
<affiliation wicri:level="1"><nlm:affiliation>Centro de Salud Pública de Castellón, Castellón, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Salud Pública de Castellón, Castellón</wicri:regionArea>
<wicri:noRegion>Castellón</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lim N Ramirez, Ram N" sort="Lim N Ramirez, Ram N" uniqKey="Lim N Ramirez R" first="Ram N" last="Lim N-Ramírez">Ram N Lim N-Ramírez</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital de la Plana, Vila-real, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital de la Plana, Vila-real</wicri:regionArea>
<wicri:noRegion>Vila-real</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perez Vilar, Silvia" sort="Perez Vilar, Silvia" uniqKey="Perez Vilar S" first="Silvia" last="Pérez-Vilar">Silvia Pérez-Vilar</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital de la Plana, Vila-real, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital de la Plana, Vila-real</wicri:regionArea>
<wicri:noRegion>Vila-real</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mic Esparza, Jose Luis" sort="Mic Esparza, Jose Luis" uniqKey="Mic Esparza J" first="José Luis" last="Mic Esparza">José Luis Mic Esparza</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Aranau de Vilanova, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Aranau de Vilanova, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tortajada Girbes, Miguel" sort="Tortajada Girbes, Miguel" uniqKey="Tortajada Girbes M" first="Miguel" last="Tortajada-Girbés">Miguel Tortajada-Girbés</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Doctor Peset, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Doctor Peset, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carratala Munuera, Concha" sort="Carratala Munuera, Concha" uniqKey="Carratala Munuera C" first="Concha" last="Carratalá-Munuera">Concha Carratalá-Munuera</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital San Juan, Alicante, Spain; Cátedra de Medicina de Familia, Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan, Alicante, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital San Juan, Alicante, Spain; Cátedra de Medicina de Familia, Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan, Alicante</wicri:regionArea>
<wicri:noRegion>Alicante</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Larrea Gonzalez, Rosa" sort="Larrea Gonzalez, Rosa" uniqKey="Larrea Gonzalez R" first="Rosa" last="Larrea-González">Rosa Larrea-González</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital General de Castellón, Castellón, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital General de Castellón, Castellón</wicri:regionArea>
<wicri:noRegion>Castellón</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Beltran Garrido, Juan Manuel" sort="Beltran Garrido, Juan Manuel" uniqKey="Beltran Garrido J" first="Juan Manuel" last="Beltrán-Garrido">Juan Manuel Beltrán-Garrido</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital General de Castellón, Castellón, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital General de Castellón, Castellón</wicri:regionArea>
<wicri:noRegion>Castellón</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Otero Reigada, Maria Del Carmen" sort="Otero Reigada, Maria Del Carmen" uniqKey="Otero Reigada M" first="Maria Del Carmen" last="Otero-Reigada">Maria Del Carmen Otero-Reigada</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario y Politécnico La Fe, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Universitario y Politécnico La Fe, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mollar Maseres, Joan" sort="Mollar Maseres, Joan" uniqKey="Mollar Maseres J" first="Joan" last="Mollar-Maseres">Joan Mollar-Maseres</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario y Politécnico La Fe, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Universitario y Politécnico La Fe, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Correcher Medina, Patricia" sort="Correcher Medina, Patricia" uniqKey="Correcher Medina P" first="Patricia" last="Correcher-Medina">Patricia Correcher-Medina</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Lluis Alcanyis, Xativa, Spain, 12 Centro de Salud San Blas, Alicante, Spain, 13 Hospital de Elda, Elda, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Lluis Alcanyis, Xativa, Spain, 12 Centro de Salud San Blas, Alicante, Spain, 13 Hospital de Elda, Elda</wicri:regionArea>
<wicri:noRegion>Elda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schwarz Chavarri, German" sort="Schwarz Chavarri, German" uniqKey="Schwarz Chavarri G" first="Germán" last="Schwarz-Chavarri">Germán Schwarz-Chavarri</name>
<affiliation wicri:level="1"><nlm:affiliation>Centro de Salud San Blas, Alicante, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Salud San Blas, Alicante</wicri:regionArea>
<wicri:noRegion>Alicante</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gil Guillen, Vicente" sort="Gil Guillen, Vicente" uniqKey="Gil Guillen V" first="Vicente" last="Gil-Guillén">Vicente Gil-Guillén</name>
<affiliation wicri:level="1"><nlm:affiliation>Cátedra de Medicina de Familia, Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan, Alicante, Spain; Hospital de Elda, Elda, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Cátedra de Medicina de Familia, Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan, Alicante, Spain; Hospital de Elda, Elda</wicri:regionArea>
<wicri:noRegion>Elda</wicri:noRegion>
</affiliation>
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</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Comparative Effectiveness Research (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hospitalization (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Spain (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Espagne (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (prévention et contrôle)</term>
<term>Hospitalisation (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Recherche comparative sur l'efficacité (MeSH)</term>
<term>Sous-type H3N2 du virus de la grippe A (immunologie)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Études prospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Comparative Effectiveness Research</term>
<term>Female</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Espagne</term>
<term>Femelle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Recherche comparative sur l'efficacité</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Most evidence of the effectiveness of influenza vaccines comes from studies conducted in primary care, but less is known about their effectiveness in preventing serious complications. Here, we examined the influenza vaccine effectiveness (IVE) against hospitalization with PCR-confirmed influenza in the predominant A(H3N2) 2011-2012 influenza season.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>A hospital-based, test-negative study was conducted in nine hospitals in Valencia, Spain. All emergency admissions with a predefined subset of symptoms were eligible. We enrolled consenting adults age 18 and over, targeted for influenza vaccination because of comorbidity, with symptoms of influenza-like-illness within seven days of admission. We estimated IVE as (1-adjusted vaccination odds ratio)*100 after accounting for major confounders, calendar time and recruitment hospital.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>The subjects included 544 positive for influenza A(H3N2) and 1,370 negative for influenza admissions. Age was an IVE modifying factor. Regardless of vaccine administration, IVE was 72% (38 to 88%) in subjects aged under 65 and 21% (-5% to 40%) in subjects aged 65 and over. By type of vaccine, the IVE of classical intramuscular split-influenza vaccine, used in subjects 18 to 64, was 68% (12% to 88%). The IVE for intradermal and virosomal influenza vaccines, used in subjects aged 65 and over, was 39% (11% to 58%) and 16% (-39% to 49%), respectively.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>The split-influenza vaccine was effective in preventing influenza-associated hospitalizations in adults aged under 65. The intradermal vaccine was moderately effective in those aged 65 and over.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2016</Year>
<Month>01</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>9</Volume>
<Issue>11</Issue>
<PubDate><Year>2014</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
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<ArticleTitle>Influenza vaccine effectiveness in preventing influenza A(H3N2)-related hospitalizations in adults targeted for vaccination by type of vaccine: a hospital-based test-negative study, 2011-2012 A(H3N2) predominant influenza season, Valencia, Spain.</ArticleTitle>
<Pagination><MedlinePgn>e112294</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0112294</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Most evidence of the effectiveness of influenza vaccines comes from studies conducted in primary care, but less is known about their effectiveness in preventing serious complications. Here, we examined the influenza vaccine effectiveness (IVE) against hospitalization with PCR-confirmed influenza in the predominant A(H3N2) 2011-2012 influenza season.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">A hospital-based, test-negative study was conducted in nine hospitals in Valencia, Spain. All emergency admissions with a predefined subset of symptoms were eligible. We enrolled consenting adults age 18 and over, targeted for influenza vaccination because of comorbidity, with symptoms of influenza-like-illness within seven days of admission. We estimated IVE as (1-adjusted vaccination odds ratio)*100 after accounting for major confounders, calendar time and recruitment hospital.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The subjects included 544 positive for influenza A(H3N2) and 1,370 negative for influenza admissions. Age was an IVE modifying factor. Regardless of vaccine administration, IVE was 72% (38 to 88%) in subjects aged under 65 and 21% (-5% to 40%) in subjects aged 65 and over. By type of vaccine, the IVE of classical intramuscular split-influenza vaccine, used in subjects 18 to 64, was 68% (12% to 88%). The IVE for intradermal and virosomal influenza vaccines, used in subjects aged 65 and over, was 39% (11% to 58%) and 16% (-39% to 49%), respectively.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The split-influenza vaccine was effective in preventing influenza-associated hospitalizations in adults aged under 65. The intradermal vaccine was moderately effective in those aged 65 and over.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Puig-Barberà</LastName>
<ForeName>Joan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain; Centro de Salud Pública de Castellón, Castellón, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>García-de-Lomas</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Instituto Valenciano de Microbiología, Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Díez-Domingo</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arnedo-Pena</LastName>
<ForeName>Alberto</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centro de Salud Pública de Castellón, Castellón, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ruiz-García</LastName>
<ForeName>Montserrat</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centro de Salud Pública de Castellón, Castellón, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Limón-Ramírez</LastName>
<ForeName>Ramón</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Hospital de la Plana, Vila-real, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pérez-Vilar</LastName>
<ForeName>Silvia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Hospital de la Plana, Vila-real, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Micó-Esparza</LastName>
<ForeName>José Luis</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>Hospital Aranau de Vilanova, Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tortajada-Girbés</LastName>
<ForeName>Miguel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Hospital Doctor Peset, Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carratalá-Munuera</LastName>
<ForeName>Concha</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Hospital San Juan, Alicante, Spain; Cátedra de Medicina de Familia, Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan, Alicante, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Larrea-González</LastName>
<ForeName>Rosa</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Hospital General de Castellón, Castellón, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Beltrán-Garrido</LastName>
<ForeName>Juan Manuel</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Hospital General de Castellón, Castellón, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Otero-Reigada</LastName>
<ForeName>Maria Del Carmen</ForeName>
<Initials>Mdel C</Initials>
<AffiliationInfo><Affiliation>Hospital Universitario y Politécnico La Fe, Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mollar-Maseres</LastName>
<ForeName>Joan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Hospital Universitario y Politécnico La Fe, Valencia, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Correcher-Medina</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Hospital Lluis Alcanyis, Xativa, Spain, 12 Centro de Salud San Blas, Alicante, Spain, 13 Hospital de Elda, Elda, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schwarz-Chavarri</LastName>
<ForeName>Germán</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Centro de Salud San Blas, Alicante, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gil-Guillén</LastName>
<ForeName>Vicente</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Cátedra de Medicina de Familia, Departamento de Medicina Clínica, Universidad Miguel Hernández, San Juan, Alicante, Spain; Hospital de Elda, Elda, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>Valencia Hospital Network for the Study of Influenza and Respiratory Virus Disease</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>11</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance>
</Chemical>
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<CitationSubset>IM</CitationSubset>
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<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
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<ForeName>Joan</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Beltrán-Garrido</LastName>
<ForeName>Juan Manuel</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Carratalá-Munuera</LastName>
<ForeName>Concha</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Correcher-Medina</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Alvanyís</LastName>
<ForeName>Lluis</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gil-Guillén</LastName>
<ForeName>Vicente</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Larrea-González</LastName>
<ForeName>Rosa</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Limón-Ramírez</LastName>
<ForeName>Ramón</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Micó-Esparza</LastName>
<ForeName>José Luis</ForeName>
<Initials>JL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>de Vilanova</LastName>
<ForeName>Arnau</ForeName>
<Initials>A</Initials>
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<ForeName>Joan</ForeName>
<Initials>J</Initials>
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<Investigator ValidYN="Y"><LastName>del Carmen Otero-Reigada</LastName>
<ForeName>Maria</ForeName>
<Initials>M</Initials>
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<Investigator ValidYN="Y"><LastName>Schwarz-Chavarri</LastName>
<ForeName>Germán</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tortajada-Girbés</LastName>
<ForeName>Miguel</ForeName>
<Initials>M</Initials>
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   |texte=   Influenza vaccine effectiveness in preventing influenza A(H3N2)-related hospitalizations in adults targeted for vaccination by type of vaccine: a hospital-based test-negative study, 2011-2012 A(H3N2) predominant influenza season, Valencia, Spain.
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Influenza vaccine effectiveness in preventing influenza A(H3N2)-related hospitalizations in adults targeted for vaccination by type of vaccine: a hospital-based test-negative study, 2011-2012 A(H3N2) predominant influenza season, Valencia, Spain.

Influenza vaccine effectiveness in preventing influenza A(H3N2)-related hospitalizations in adults targeted for vaccination by type of vaccine: a hospital-based test-negative study, 2011-2012 A(H3N2) predominant influenza season, Valencia, Spain.

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